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New paraconic acids from the endophytic fungus Xylariaceae sp. J4
Chao Yuan1, Xue-Chun Shu2, Lin Fan3
1Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Hainan Provincial Engineering Research Center for Tropical Medicinal Plants, Danzhou, People's Republic of China.
Abstract:
Three new paraconic acids, xylariacinics A-C (1-3), were isolated from the endophyte Xylariaceae sp. J4 harbored in the medicinal plant Blumea balsamifera. Their structures were elucidated on the basis of extensive spectroscopic data including HRMS, and NMR. The antibacterial efficacies of compounds 1-3 were evaluated against a panel of bacteria such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. Their antifungal activities were also tested against Colletotrichum gloeosporioides. Unfortunately, all of them were inactive.
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