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Pharmacological management of cardiovascular risk in chronic inflammatory rheumatic diseases

Vasileios Panoulas1,2, George D Kitas3,4

  • 1Cardiology Department, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust , London, UK.

Expert Review of Clinical Pharmacology
|May 23, 2020
PubMed

Insights

Patients with chronic inflammatory rheumatic diseases have increased cardiovascular disease (CVD) risk. Effective management of dyslipidemia, hypertension, and diabetes is crucial for improving outcomes in these individuals.

Area of Science:

  • Rheumatology
  • Cardiology
  • Pharmacology

Background:

  • Cardiovascular comorbidity significantly impacts outcomes in chronic inflammatory rheumatic diseases.
  • Key risk factors include dyslipidemia, hypertension, and impaired glucose tolerance, requiring regular assessment.
  • Optimal management of the underlying inflammatory condition is essential.

Purpose of the Study:

  • To review pharmacological management of cardiovascular risk factors in chronic inflammatory rheumatic diseases.
  • To discuss current and emerging therapies for dyslipidemia, hypertension, and diabetes in this patient population.
  • To provide practical guidance for risk factor management based on existing data.

Main Methods:

  • Critical review of manuscripts and guidelines using major scientific databases (PubMed, MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar).
  • Focus on pharmacological interventions for dyslipidemia, hypertension, and diabetes.
  • Literature search up to March 1, 2020.

Main Results:

  • Lifestyle modifications are fundamental for managing cardiovascular risk factors.
  • Pharmacological therapies are available to help patients achieve treatment targets.
  • Emerging therapies offer future potential for improved management.

Conclusions:

  • Cardiovascular disease risk is elevated in patients with chronic inflammatory rheumatic diseases.
  • Cardiovascular risk factor management is a critical component of patient care.
  • Gaps in knowledge and implementation of management strategies persist, necessitating practical guidance.
Abstract

Keywords:
Pharmacologicalcardiovasculardiabetesdyslipidaemiahypertensioninflammatory joint diseaserheumatoid arthritisrisk

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