Related Experiment Video
Updated: Aug 14, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
11-Deoxycorticosterone-induced hypertension, glomerulosclerosis and renal arterial and arteriolar lesions
1Department of Pathology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.
Abstract:
Glomerulosclerosis and vascular lesions occurring in rats receiving 11-deoxycorticosterone and salt-loading have been studied in order to examine their relationship. The glomerular lesion started as focal segmental sclerosis. The globally sclerosed glomeruli were enlarged in size, demonstrating that these showed no evidence of ischemic atrophy. Advanced glomerulosclerosis occurred independent of preglomerular arteriolar pathologic lesion. No meaningful structural changes were observed in the arterial system. In conclusion, DOC-salt-induced glomerulosclerosis started as segmental lesion, occurred independent of structural alterations in the preglomerular arterioles, and took place without evidence of intrarenal arterial stenosis. Further studies are necessary to clarify about the role of hemodynamic stress-related injury to glomerular microcirculatory system as a major cause for DOC-Salt-induced glomerulosclerosis.
Related Concept Videos
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Direct Renin Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Diabetic Nephropathy

