Related Experiment Video
Updated: Dec 20, 2025

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Scaffolding-Induced Property Modulation of Chemical Space
Jingyao Li1, Vincenzo Di Lorenzo1,2, Pravin Patil1
1Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Abstract:
Physicochemical property switching of chemical space is of great importance for optimization of compounds, for example, for biological activity. Cyclization is a key method to control 3D and other properties. A two-step approach, which involves a multicomponent reaction followed by cyclization, is reported to achieve the transition from basic moieties to charge neutral cyclic derivatives. A series of multisubstituted oxazolidinones, oxazinanones, and oxazepanones as well as their thio and sulfur derivatives are synthesized from readily available building blocks with mild conditions and high yields. Like a few other methods, MCR and cyclization allow for the collective transformation of a large chemical space into a related one with different properties.
More Related Videos
11:13Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
07:14Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Related Concept Videos
Inductive Effects on Chemical Shift: Overview
Molecular Models
Molecular Orbital Theory II
π Electron Effects on Chemical Shift: Overview
NMR Spectroscopy: Chemical Shift Overview
For instance, the proton...
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement