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Effect of methotrexate on local cerebral blood flow in conscious rats
S Mizusawa1, Y Kondoh, M Murakami
1Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita, Japan.
Japanese Journal of Pharmacology
|December 1, 1988
Abstract:
The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.