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Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications
Michelle Roytman1, David J Pisapia2, Benjamin Liechty2
1Department of Radiology, Weill Cornell Medicine-New York Presbyterian Hospital, United States of America.
Clinical Imaging
|May 23, 2020
Summary
This study details an atypical meningioma that showed low uptake on Gallium-68 DOTATATE PET/MRI. Immunohistochemistry confirmed it was somatostatin receptor subtype 2 (SSTR2)-negative, challenging typical imaging findings.
Area of Science:
- Neuro-oncology
- Nuclear Medicine
- Radiology
Background:
- Meningiomas are common intracranial tumors, typically expressing somatostatin receptors (SSTR), especially SSTR2.
- 68Ga-DOTATATE PET/MRI is increasingly used for meningioma evaluation due to its SSTR2 targeting.
- Previous studies on SSTR negativity used less accurate imaging agents or methods.
