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Related Experiment Video

Updated: Dec 20, 2025

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
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Paediatric aortic valve replacement using decellularized allografts.

Alexander Horke1, Dmitry Bobylev1, Murat Avsar1

  • 1Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|May 23, 2020
PubMed
Summary

Decellularized aortic homografts (DAHs) offer a promising new option for pediatric aortic valve replacement when repair is not possible. These grafts show excellent short-term results and potentially fewer complications than other procedures.

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Pediatric Cardiology

Background:

  • Limited options exist for pediatric aortic valve replacement (AVR) when valve repair is not feasible.
Keywords:
AllograftsAortic valve diseaseChildrenDecellularization

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  • The Ross procedure has inferior outcomes in children compared to adults.
  • Mechanical AVR requires lifelong anticoagulation with associated risks.