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Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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Asepsis01:28

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Related Experiment Video

Updated: Dec 20, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Sepsis Associated Delirium.

Ben Atterton1, Maria Carolina Paulino2, Pedro Povoa2,3,4

  • 1Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, St. James Street, Dublin 8, Dublin D08 NHY1, Ireland.

Medicina (Kaunas, Lithuania)
|May 24, 2020
PubMed
Summary
This summary is machine-generated.

Sepsis-associated delirium (SAD) is a brain dysfunction during sepsis, potentially causing long-term neurological issues. Early detection via screening tools is crucial for managing SAD and improving sepsis survivor rehabilitation.

Keywords:
ICUdeliriumdexmedetomidinesepsis

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Area of Science:

  • Neuroscience
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Sepsis triggers a systemic host response, often affecting the brain.
  • Sepsis-associated delirium (SAD) presents as confusion or coma, linked to neuroinflammation and altered brain function.
  • Neurological deficits from SAD can hinder sepsis survivor recovery.

Purpose of the Study:

  • To review the understanding and management of sepsis-associated delirium.
  • To highlight the importance of early SAD identification and treatment.
  • To discuss diagnostic controversies and treatment guidelines for SAD.

Main Methods:

  • Literature review of sepsis-associated delirium.
  • Analysis of clinical manifestations and proposed pathophysiological mechanisms.
  • Examination of diagnostic tools and current treatment recommendations.

Main Results:

  • Sepsis significantly impacts brain function, leading to SAD.
  • Early identification of SAD through screening tools is vital for prompt intervention.
  • The role of biomarkers, neuroimaging, and EEG in SAD diagnosis is still debated.
  • Pharmacological treatment for SAD is generally not recommended unless symptoms are severe.

Conclusions:

  • Sepsis-associated delirium is a serious complication with potential long-term neurological consequences.
  • Prompt identification and management of underlying sepsis are key to controlling SAD.
  • Validated screening tools are essential for early SAD detection and management.
  • Current guidelines recommend conservative treatment for SAD, focusing on non-pharmacological interventions.