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Effect of c-myc gene expression on early inducible reactions required for erythroid differentiation in vitro
T Kaneko-Ishino1, T U Kume, H Sasaki
1Institute of Applied Microbiology, University of Tokyo, Japan.
Molecular and Cellular Biology
|December 1, 1988
Abstract:
By employing cell fusion between two genetically marked mouse erythroleukemia (MEL) cells in which an artificially introduced c-myc gene had been placed under the control of human metallothionein promoter, we investigated the mechanism of the suppressive action of c-myc gene expression in erythroid differentiation. The results indicated that the expression of the c-myc gene blocked the induction of dimethyl sulfoxide-inducible activity, one of the two early activities required for triggering the differentiation.