Effective support following recurrent pregnancy loss: a randomized controlled feasibility and acceptability study.

Area of Science:

• Reproductive Medicine
• Psychological Interventions
• Clinical Trial Feasibility

Background:

• Recurrent pregnancy loss (RPL) significantly impacts women's psychological well-being.
• There is a need for effective interventions to support women during early stages of subsequent pregnancies after RPL.

Purpose of the Study:

• To assess the feasibility of conducting a multicentre randomized controlled trial (RCT) for the positive reappraisal coping intervention (PRCI).
• To evaluate the potential effectiveness of PRCI in improving psychological well-being among women with RPL.

Main Methods:

• A mixed-method study incorporating a randomized controlled trial (RCT) and a qualitative process evaluation (QPE).
• Participants (n=75) were recruited; 47 were randomized upon a positive pregnancy test.
• Intervention group received PRCI and weekly assessments; control group received weekly assessments.

Main Results:

• The study successfully gathered feasibility data for a future definitive trial.
• Participants were receptive to the PRCI, indicating potential benefits without apparent downsides.

Conclusions:

• A definitive RCT of the PRCI for women with RPL is feasible.
• The PRCI is a potentially safe, low-cost, convenient, and easily deliverable intervention for a vulnerable population.