Related Experiment Video
Updated: Dec 20, 2025
07:27
A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
19.0K
Malaria, Collapsing Glomerulopathy, and Focal and Segmental Glomerulosclerosis
Ariane Amoura1,2, Anissa Moktefi2,3, Matthieu Halfon4
1Assistance Publique des Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Créteil, France.
Summary
Imported malaria, especially Plasmodium falciparum, can cause kidney disease like focal segmental glomerulosclerosis (FSGS) in individuals of African ancestry. This may be linked to APOL1 gene variants, particularly in those with HIV.
Area of Science:
- Nephrology
- Infectious Diseases
- Genetics
Background:
- Malaria is a prevalent global infectious disease with poorly understood kidney complications.
- Glomerular involvement post-malaria remains under-described in contemporary medical literature.
Purpose of the Study:
- To investigate the clinical, biological, pathological, and therapeutic aspects of glomerular disease in patients post-malaria.
- To assess kidney biopsy findings in patients presenting with malaria within three months of infection.
Main Methods:
- Retrospective multicenter study of 23 patients with malaria and biopsy-proven glomerular disease.
- Analysis of clinical data, laboratory results, kidney pathology, and treatment outcomes.
- Genetic testing for APOL1 risk variants.
Main Results:
- 23 patients, mostly of African ancestry, with 10 having concomitant HIV infection.
- Plasmodium falciparum was the predominant species.
- Focal segmental glomerulosclerosis (FSGS) was found in 21 patients, with 18 showing collapsing glomerulopathy.
- Acute kidney injury (AKI) requiring kidney replacement therapy (KRT) occurred in 12 patients.
Conclusions:
- Imported Plasmodium infection may be a novel cause of secondary FSGS, especially collapsing glomerulopathy.
- This risk is heightened in individuals of African ancestry with high-risk APOL1 variants.
- Co-infection with HIV may exacerbate these kidney injuries.
Keywords:
APOL1 proteinFSGSFollow-Up StudiesHIV InfectionsHIV-Associated Nephropathycollapsing glomerulopathyhumanimmunohistochemistrymalaria infectionminimal change nephrotic syndrome; kidney biopsynephrotic syndromeMore Related Videos
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
398
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
398
01:20Renal Corpuscle
6.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.6K
01:10Nephrons
5.9K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
5.9K
01:24Chronic Kidney Disease II: Clinical Manifestations
454
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
454
01:29Acute Kidney Injury II: Pathophysiology
720
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
720
01:27Glucose Transporters
27.0K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
27.0K