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Clinical features of rheumatic patients infected with COVID-19 in Wuhan, China

Cong Ye1, Shaozhe Cai1, Guifen Shen1

  • 1Department of Rheumatology and Immunology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

Annals of the Rheumatic Diseases
|May 24, 2020
PubMed

Insights

Rheumatic patients with coronavirus disease 2019 (COVID-19) had higher rates of respiratory failure. Differentiating COVID-19 from rheumatic disease flares is crucial for effective clinical management.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Clinical features of coronavirus disease 2019 (COVID-19) in rheumatic patients remain largely unreported.
  • Understanding these features is vital for clinical practice and patient management.

Purpose of the Study:

  • To describe the clinical characteristics of COVID-19 in patients with rheumatic diseases.
  • To provide insights for managing rheumatic patients during the COVID-19 pandemic.

Main Methods:

  • A retrospective case series was conducted.
  • Data from 2326 COVID-19 patients, including 21 with rheumatic disease, were analyzed.

Main Results:

  • Rheumatic patients showed higher incidence of respiratory failure (38% vs. 10%) but similar hospital stay and mortality rates compared to non-rheumatic patients.
  • Common symptoms included fever, fatigue, and diarrhea; four patients experienced rheumatic disease flares.
  • Lymphocytopenia was frequent (57%) in rheumatic cases; hydroxychloroquine use was associated with non-critical illness.

Conclusions:

  • Respiratory failure is a significant concern for rheumatic patients with COVID-19.
  • Clinical differentiation between COVID-19 and rheumatic disease flares is essential.
Abstract

Keywords:
autoimmune diseasesautoimmunityinflammation

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