Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

680
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
680

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Anesthetic and analgesic management of Svalbard rock ptarmigan (Lagopus muta hyperborea) undergoing experimental stereotaxic neurosurgery.

BMC veterinary research·2026
Same author

Spermidine in Alzheimer's Disease: Evidence from Animal Models and Human Studies.

Degenerative neurological and neuromuscular disease·2026
Same author

Willingness and barriers to blood-based biomarker testing of Alzheimer's disease in the general population in the Czech Republic.

Alzheimer's research & therapy·2026
Same author

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.

Nature aging·2026
Same author

Associations of lifestyle and health factors with subjective memory complaints in a large cohort of mHealth users.

Aging & mental health·2026
Same author

Challenging memory tests in early Alzheimer's disease: From research to clinical practice.

Neuroscience and biobehavioral reviews·2026

Related Experiment Video

Updated: Dec 20, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.0K

Spatial Pattern Separation in Early Alzheimer's Disease.

Martina Parizkova1,2, Ondrej Lerch1,2, Ross Andel1,2,3

  • 1Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.

Journal of Alzheimer'S Disease : JAD
|May 24, 2020
PubMed
Summary
This summary is machine-generated.

Spatial pattern separation is impaired in early Alzheimer's disease (AD). Reduced volumes in the hippocampus and basal forebrain nuclei correlate with this impairment, potentially causing spatial memory deficits in AD patients.

Keywords:
Basal forebrainentorhinal cortexhippocampusmemorymild cognitive impairment

More Related Videos

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

33.6K
Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

13.9K

Related Experiment Videos

Last Updated: Dec 20, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.0K
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

33.6K
Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

13.9K

Area of Science:

  • Neuroscience
  • Alzheimer's Disease Research
  • Cognitive Neurology

Background:

  • Alzheimer's disease (AD) initially affects brain regions crucial for spatial memory, including the hippocampus, entorhinal cortex, and basal forebrain.
  • These regions are vital for spatial pattern separation, a cognitive process essential for distinguishing similar spatial environments.

Purpose of the Study:

  • To investigate spatial pattern separation abilities in early-stage Alzheimer's disease.
  • To determine the association between spatial pattern separation and volumetric changes in the hippocampus, entorhinal cortex, and basal forebrain nuclei (medial septal nuclei and Ch1-2 nuclei).

Main Methods:

  • 98 older adults, including those with amnestic mild cognitive impairment (aMCI) due to AD, mild AD dementia, and cognitively normal (CN) individuals, were recruited.
  • Participants underwent spatial pattern separation testing, cognitive assessments, and MRI brain volumetry.

Main Results:

  • Spatial pattern separation accuracy was significantly lower in individuals with early AD compared to controls (p < 0.001).
  • Performance decreased with increasing disease severity (CN > aMCI > AD dementia).
  • Hippocampal and Ch1-2 nuclei volumes directly correlated with spatial pattern separation, while the entorhinal cortex's influence was indirect via the hippocampus.

Conclusions:

  • Impaired spatial pattern separation is a characteristic of early Alzheimer's disease.
  • Reduced volumes in the hippocampus, entorhinal cortex, and basal forebrain Ch1-2 nuclei are linked to this impairment.
  • These structural changes may underlie the spatial memory deficits observed in Alzheimer's disease.