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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Pleiotropy01:33

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Epigenetics of Psoriasis.

Shuai Shao1,2, Johann E Gudjonsson3

  • 1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi, China.

Advances in Experimental Medicine and Biology
|May 24, 2020
PubMed
Summary
This summary is machine-generated.

Psoriasis pathogenesis involves T cell immune disorders and epigenetic factors like DNA methylation. Emerging epigenetic therapies show promise for treating this chronic inflammatory skin condition.

Keywords:
EpigeneticsInflammationPsoriasisSkin

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Area of Science:

  • Dermatology
  • Immunology
  • Epigenetics

Background:

  • Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte proliferation and T cell activation.
  • Its central pathogenesis is a T cell-dominant immune disorder influenced by genetics and environment.
  • The precise etiology remains largely unknown, with recent focus on epigenetic mechanisms.

Purpose of the Study:

  • To review current findings on the role of epigenetics in psoriasis pathogenesis.
  • To discuss the interplay of epigenetic factors in psoriasis.
  • To explore future therapeutic perspectives targeting epigenetic modifications.

Main Methods:

  • Literature review of studies on psoriasis and epigenetics.
  • Analysis of epigenetic mechanisms including DNA methylation, chromatin modifications, and noncoding RNAs.
  • Examination of emerging epigenetic therapies.

Main Results:

  • Epigenetic factors such as DNA methylation, chromatin modifications, and noncoding RNAs are critical in psoriasis pathogenesis.
  • The interplay between these epigenetic factors is beginning to be understood.
  • Inhibitors of epigenetic enzymes (e.g., DNA methyltransferases, histone deacetylases) show therapeutic potential.

Conclusions:

  • Epigenetic dysregulation plays a significant role in the pathogenesis of psoriasis.
  • Targeting epigenetic modifications offers novel therapeutic strategies for psoriasis treatment.
  • Further research into the interplay of epigenetic factors is crucial for advancing psoriasis care.