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Drug Dosing in Patients Undergoing Therapeutic Plasma Exchange
Sherif Hanafy Mahmoud1, Jessica Buhler2, Eric Chu2
1Faculty of Pharmacy and Pharmaceutical Sciences, 3-142H, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada. smahmoud@ualberta.ca.
Neurocritical Care
|May 24, 2020
Summary
Therapeutic plasma exchange (TPE) removes substances from blood plasma. This review examines TPE
Area of Science:
- Neurology
- Pharmacology
- Nephrology
Background:
- Therapeutic plasma exchange (TPE) is an extracorporeal procedure that removes plasma from blood.
- TPE is increasingly used in neurocritical care for autoimmune neurological disorders.
- TPE can unintentionally remove medications from circulation.
Purpose of the Study:
- To review current evidence on drug removal during TPE.
- To offer clinical guidance for managing drug removal by TPE.
- To develop a tool for predicting drug removal potential.
Main Methods:
- Literature review of studies on TPE and drug removal.
- Analysis of pharmacokinetic and procedure-specific factors influencing drug removal.
- Synthesis of clinical data and expert opinion.
Main Results:
- Drug removal by TPE varies significantly based on drug properties and TPE parameters.
- Certain drugs are highly susceptible to removal, necessitating dose adjustments.
- TPE can impact the efficacy of essential medications.
Conclusions:
- Understanding drug removal during TPE is crucial for patient safety and treatment efficacy.
- Clinical guidelines are needed to manage drug therapy during TPE.
- Predictive tools can aid clinicians in optimizing medication regimens during TPE.
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