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Association between the IL-6, IL-10, and TNFα gene polymorphisms and preterm-birth in Korean women

Seung Hun Han1, Noo Ri Lee1, Hyung Jun Kim1

  • 1Department of Biological Sciences, College of Natural Science, Dankook University, Cheonan, South Korea.

Genes & Genomics
|May 24, 2020
PubMed

Insights

Genetic variations in immune genes like IL-10 are linked to preterm birth (PTB) in Korean women. Specific gene polymorphisms and combined genotypes showed significant associations with PTB development and birth weight.

Area of Science:

  • Immunogenetics
  • Reproductive Medicine
  • Perinatal Health

Background:

  • Preterm birth (PTB) is a leading cause of neonatal and maternal mortality.
  • Both genetic and environmental factors contribute to PTB.
  • Immune system genes, including IL-6, IL-10, and TNFα, have been implicated in PTB.

Purpose of the Study:

  • To investigate the genetic association between specific polymorphisms in IL-6 (rs1800796), IL-10 (rs1800872), and TNFα (rs1800630) and PTB.
  • To analyze these associations in a Korean population.

Main Methods:

  • Study included 115 PTB cases and 147 controls.
  • Genotyping of single nucleotide polymorphisms (SNPs) was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Main Results:

  • The IL-10 rs1800872 polymorphism showed a significant association with PTB genotype frequency (OR 1.71, p=0.046).
  • Combined genotypes (rs1800796 CC, rs1800872 CA, rs1800630 CA) were significantly associated with PTB (OR 7.43, p=0.001).
  • The rs1800630 A allele correlated with increased birth weight in PTB patients (p=0.005).

Conclusions:

  • The studied polymorphisms in IL-6, IL-10, and TNFα may be associated with the development of preterm birth.
  • These findings suggest a potential genetic contribution of these immune-related genes to PTB.
Abstract

Keywords:
Genetic associationIL-10IL-6PolymorphismPreterm birthTNFα

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