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Clonal relationship in multisited mucosa-associated lymphoid tissue lymphomas: a single-centre experience
Maria Condom1, Fina Climent2, Davinia Fernández2
1Department of Hematology, Institut Català d'Oncologia, Hospital Duran i Reynals- IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
British Journal of Haematology
|May 24, 2020
Summary
Multisited mucosa-associated lymphoid tissue (MALT) lymphomas often share the same clone, but distinct clones in late relapses suggest de novo neoplasms, possibly due to genetic predisposition.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Clonal heterogeneity is well-studied in lymphoid neoplasms but underexplored in mucosa-associated lymphoid tissue (MALT) lymphomas.
- Multisited MALT lymphomas present unique challenges in understanding disease origin and behavior.
Purpose of the Study:
- To investigate clonal heterogeneity in multisited MALT lymphomas.
- To differentiate between true relapse and de novo development in late-relapsing MALT lymphomas.
Main Methods:
- Retrospective analysis of 91 patients diagnosed with multisited MALT lymphoma (2009-2018).
- Molecular studies using polymerase chain reaction to detect clonally rearranged immunoglobulin in affected organs.
Main Results:
- 28 patients had multisited disease; clonality studies were performed in 16.
- Four cases (25%) exhibited clonal heterogeneity across different involved organs.
- Late relapses (two patients) showed distinct clones, suggesting de novo development rather than relapse.
Conclusions:
- Most multisited MALT lymphomas involve a single clone, but distinct clones in late relapses indicate potential de novo neoplasms.
- This finding may imply a genetic predisposition in some patients and has implications for treatment strategies.
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