Related Experiment Video
Updated: Dec 20, 2025

Engineered Lung Tissues Prepared from Decellularized Lung Slices
Published on: January 21, 2022
Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration
1Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
Abstract:
The renewal of lung epithelial cells is normally slow unless the lung is injured. The resident epithelial stem cells rapidly proliferate and differentiate to maintain lung structure and function when the lung is damaged. The alveolar epithelium is characterized by alveolar type 1 (AT1) and alveolar type 2 (AT2) cells. AT2 cells are the stem cells for alveoli, as they can both self-renew and generate AT1 cells. Abnormal proliferation and regulation of AT2 cells will lead to serious lung diseases including cancers. In this review, we focused on the alveolar stem/progenitor cells, the key physiological function of AT2 cells in lung homeostasis and the complicated regulation of AT2 cells in the repairing processes after lung injury.
More Related Videos
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Tissue Renewal without Stem Cells
However, failure of such a system...
Stem Cell Niche
Multipotency of Hematopoietic Stem Cells
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...

