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Related Experiment Video

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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Published on: June 8, 2014

Extra-skeletal effects of bisphosphonates.

Argyro Panagiotakou¹, Maria Yavropoulou², Narjes Nasiri-Ansari¹

¹Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Greece.

Metabolism: Clinical and Experimental

|May 24, 2020

Summary

Bisphosphonates (BPs), used for bone diseases, are now recognized for significant non-skeletal effects, including anti-tumor and anti-diabetic actions. Research explores these extra-skeletal benefits and novel delivery systems for expanded therapeutic applications.

Keywords:

Bisphosphonates CVD risk Cancer Diabetes Estrogens Extra-skeletal Inflammation

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Published on: September 26, 2016

Area of Science:

Pharmacology
Biochemistry
Drug Delivery

Background:

Bisphosphonates (BPs) are pyrophosphate analogues with high affinity for bone hydroxyapatite, primarily used for bone loss and turnover diseases.
Recent data reveal extra-skeletal tissue deposition and diverse non-skeletal effects of BPs.
These effects include anti-tumor, immunomodulatory, anti-inflammatory, and anti-diabetic activities.

Purpose of the Study:

To review current data on the extra-skeletal actions of bisphosphonates.
To explore the underlying pathophysiological mechanisms of these non-skeletal effects.
To highlight advancements in delivery systems for expanded therapeutic applications.

Main Methods:

Literature review of studies published in the last decade.
Analysis of data on bisphosphonate tissue deposition and biological effects.
Examination of novel drug delivery systems for bisphosphonates.

Main Results:

Bisphosphonates demonstrate significant extra-skeletal effects beyond bone targeting.
Identified non-skeletal actions include anti-tumor, immunomodulatory, anti-inflammatory, and anti-diabetic properties.
New delivery systems like liposomes and nanoparticles are being developed to target extra-skeletal tissues.

Conclusions:

Bisphosphonates possess a broader therapeutic potential than previously recognized, extending to non-skeletal conditions.
Understanding the mechanisms of extra-skeletal actions is crucial for optimizing BP therapy.
Advanced delivery systems promise to enhance the efficacy and expand the clinical use of bisphosphonates in various diseases.