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Updated: Dec 20, 2025

Generation of Mice Derived from Induced Pluripotent Stem Cells
Published on: November 29, 2012
Generation of a human iPSC line (MPIi006-A) from a patient with Pelizaeus-Merzbacher disease
Kee-Pyo Kim1, Juyong Yoon1, Borami Shin1
1Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, Münster 48149, Germany.
Abstract:
We established a human induced pluripotent stem cells (hiPSC) line (MPIi006-A) from fibroblasts of a 20-year-old male Pelizaeus-Merzbacher disease (PMD) patient with a hemizygous 643C>T mutation in proteolipid protein 1 (PLP1) gene using a retroviral delivery of OCT4, SOX2, KLF4 and c-MYC. The MPIi006-A iPSC line carried the mutation, displayed typical iPSC morphology, expressed pluripotent stem cell makers, exhibited normal karyotype and were capable of differentiating into cells representative of three germ layers.
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