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Histopathologic changes in cadaver eyes after MicroPulse and continuous wave transscleral cyclophotocoagulation.
Jessica S Maslin1, Peter P Chen2, John Sinard3
1University of Southern California Roski Eye Institute, Los Angeles, CA.
Summary
MicroPulse transscleral cyclophotocoagulation (MPCPC) caused less ciliary body damage than continuous wave (CW) treatments in human eyes. MPCPC appears to be a more selective and less destructive cyclophotocoagulation method.
Area of Science:
- Ophthalmology
- Histopathology
- Surgical Technology
Background:
- Transscleral cyclophotocoagulation is used to treat glaucoma.
- Continuous wave (CW) and MicroPulse (MP) modalities exist.
- Histological effects of these modalities require comparison.
Purpose of the Study:
- Compare acute histological effects of MPCPC and CWCPC.
- Evaluate ciliary body and adjacent structure damage.
- Utilize human cadaver eyes for analysis.
Main Methods:
- Human cadaver eyes were treated with CWCPC, slow burn CWCPC, or MPCPC.
- Untreated quadrants served as controls.
- Histological processing and light microscopy by a blinded pathologist were performed.
Main Results:
- CWCPC treatments caused variable coagulative tissue damage to the ciliary body.
- MPCPC treatment resulted in minimal coagulative tissue damage.
- Both methods showed pigment clumping/streaming in the ciliary epithelium.
Conclusions:
- MPCPC caused less tissue disruption than CWCPC in human cadaver eyes.
- MPCPC may offer a less destructive and more selective cyclophotocoagulation approach.
- Further clinical studies are warranted to confirm these findings.
