Related Experiment Video
Updated: Dec 20, 2025
09:57
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
3.2K
Epilepsy and Electroencephalographic Abnormalities in SATB2-Associated Syndrome
Hannah Lewis1, Debopam Samanta2, Jenny-Li Örsell3
1University of Arkansas for Medical Sciences School of Medicine, Little Rock, Arkansas.
Pediatric Neurology
|May 25, 2020
Summary
Epileptiform abnormalities are common in SATB2-associated syndrome. Electroencephalography, especially during sleep, is recommended for early detection and management of seizures in these individuals.
Area of Science:
- Neurology
- Genetics
- Epileptology
Background:
- Seizures are an under-recognized aspect of SATB2-associated syndrome.
- This study focuses on electroencephalographic (EEG) findings, seizure types, and treatment in this population.
Purpose of the Study:
- To characterize EEG abnormalities and seizure semiology in individuals with SATB2-associated syndrome.
- To evaluate treatment responses and neuroimaging findings in relation to seizures.
Main Methods:
- Retrospective review of 101 individuals with SATB2-associated syndrome and prior EEG studies.
- Supplemental caregiver surveys and neurologist input were obtained.
Main Results:
- 41 subjects (41%) had abnormal EEGs, with 93% showing epileptiform discharges, often centrally located.
- Seizures were diagnosed in 42% of subjects, with focal seizures being most common.
- Delayed myelination or white matter changes were observed in 61% of individuals.
Conclusions:
- Epileptiform abnormalities are frequent in SATB2-associated syndrome.
- Baseline EEG, including sleep, is recommended for all individuals with SATB2-associated syndrome for early epilepsy detection.
Related Concept Videos
01:24Epilepsy and Seizures: Overview
1.0K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.0K
01:13Seizures: Classification
1.2K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
716
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
716