Myeloid-derived suppressor cells exert immunosuppressive function on the T helper 2 in mice infected with
Xiaojing Zhou1, Wen Wang2, Fang Cui2
1College of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, China; Department of Neurology, Shimane University Faculty of Medicine, Izumo, 6938501, Japan.
Abstract:
Cystic echinococcosis (CE) is a worldwide hazardous zoonotic parasitosis caused by Echinococcus granulosus. CE development involves complex immunological mechanisms, including participation of multiple immune cells and effector molecules. Myeloid-derived suppressor cells (MDSCs) are known to be involved in chronic and acute inflammatory conditions. In this study, we aimed to characterize the immune function of MDSCs in CE to improve the understanding, prevention and treatment of CE. Our results indicated that MDSCs overexpressing Ly6C and Ly6G inhibit the formation and activity of T helper 2 cells in a NO-dependent manner during E. granulosus infection.
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