Older, non-demented apolipoprotein ε₄ carrier males show hyperactivation and structural differences in odor memory...

The current study sought to examine the interaction of sex and Apolipoprotein ε₄ status on olfactory recognition memory within non-demented, older individuals. We separated 39 participants into groups based on ε₄ status and sex. Each participant completed an olfactory memory recognition task during 2 functional magnetic resonance imaging scans and 1 structural scan. The ε₄ carriers had greater functional recruitment of memory regions during false positives relative to ε₄ non-carriers. During hits, the male ε₄ carriers showed greater functional recruitment compared to female ε₄ carriers. The ε₄ carriers had larger bilateral putamen volumes relative to ε₄ non-carriers. Neuroimaging data were significantly associated with Dementia Rating Scale scores solely in males. Results suggest differential olfactory memory processing in relation to sex and ε₄ status. Male ε₄ carriers in particular, demonstrated hyperactivation during recognition memory, which we suspect reflects neuronal compensation to maintain functional performance. Future studies should consider examining underlying mechanisms that contribute to these sex differences within ε₄ carriers.