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Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old

Tengyi Cai1, Vasiliki Karlaftis1, Stephen Hearps1

  • 1Murdoch Children's Research Institute, Parkville, Australia.

Pediatric Nephrology (Berlin, Germany)
|May 25, 2020
PubMed

Insights

This study established continuous paediatric reference intervals for serum cystatin C (CysC) in children. These new reference intervals account for age, blood group, and gender, improving kidney function assessment.

Area of Science:

  • Clinical Biochemistry
  • Paediatric Nephrology

Background:

  • Serum cystatin C (CysC) offers superior accuracy and sensitivity for assessing kidney function compared to creatinine.
  • Accurate and sensitive biomarkers are crucial for early detection and management of kidney disease in children.

Purpose of the Study:

  • To establish continuous paediatric reference intervals (RIs) for serum CysC.
  • To facilitate the clinical application of serum CysC as a reliable biomarker for paediatric kidney function.

Main Methods:

  • Serum CysC levels were measured in healthy term neonates and children (30 days to 18 years).
  • Immunoturbidimetric methods were employed for serum CysC quantification.
  • Fractional polynomial and quantile regression models were utilized to generate continuous RIs.

Main Results:

  • A total of 378 samples (equal male/female distribution) were analyzed.
  • No outliers were detected in the serum CysC data.
  • Continuous RIs were successfully generated and presented as equations and graphical scatterplots.

Conclusions:

  • Continuous paediatric reference intervals for serum CysC were successfully established.
  • The generated RIs demonstrate dynamic, age-based changes in serum CysC levels.
  • Significant blood group and gender-specific differences were identified for serum CysC.
Abstract

Keywords:
Continuous reference intervalsKidney functionPaediatricSerum cystatin C

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