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Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry

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Advances in extracellular vesicles analysis.

Arada Vinaiphat¹, Siu Kwan Sze¹

¹School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Advances in Clinical Chemistry

|May 26, 2020

Summary

Extracellular vesicles (EVs) are crucial for cell communication and hold potential as drug delivery vehicles and diagnostic biomarkers. This review covers advancements in EV analysis for therapeutic and diagnostic applications.

Keywords:

Biomarkers Drug delivery Exosomes Extracellular vesicles Extracellular vesicles analysis

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Characterizing Extracellular Vesicles from Biological Fluids

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

Area of Science:

Biochemistry
Cell Biology
Biotechnology

Background:

Extracellular vesicles (EVs) mediate intercellular communication by transferring cellular contents.
EVs are being explored for therapeutic drug delivery due to their ability to influence target cell functions.
The unique molecular cargo of EVs makes them promising diagnostic biomarkers.

Purpose of the Study:

To review current progress in extracellular vesicle (EV) analysis.
To discuss the transition of EVs from research to therapeutic applications.
To highlight advanced technologies for characterizing and quantifying EV subclasses.

Main Methods:

Review of current literature on EV analysis and applications.
Emphasis on integrated qualitative and quantitative analytical approaches.
Focus on EV analysis in various clinical tissue and body fluid samples.

Main Results:

EVs are versatile in intercellular communication, drug delivery, and diagnostics.
Advanced technologies are enabling detailed characterization and quantification of EV subclasses.
Integration of technologies facilitates comprehensive EV analysis.

Conclusions:

Extracellular vesicle (EV) analysis is advancing rapidly, bridging research and clinical applications.
Pioneered analytical approaches are enhancing the understanding and utility of EVs.
The integration of advanced technologies is key to unlocking the full potential of EVs in medicine.