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Updated: Dec 20, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Update on Partial Breast Irradiation.

Jaroslaw T Hepel¹, David E Wazer¹

¹Department of Radiation Oncology, Lifespan Cancer Institute, Alpert Medical School of Brown University, Providence, RI.

Clinical Breast Cancer

|May 26, 2020

Summary

This summary is machine-generated.

Partial breast irradiation (PBI) offers reduced radiation exposure for early-stage breast cancer patients. Randomized trials confirm its efficacy compared to whole breast irradiation, supporting wider adoption in breast-conserving surgery.

Keywords:

APBI Breast cancer PBI Radiation

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Area of Science:

Oncology
Radiation Oncology
Surgical Oncology

Background:

Partial breast irradiation (PBI) targets radiation to the lumpectomy site, reducing normal tissue exposure after breast-conserving surgery.
Phase 2 data supported PBI, but widespread adoption awaited randomized controlled trial (RCT) results.

Purpose of the Study:

To review RCTs comparing whole breast irradiation (WBI) with PBI for early-stage breast cancer.
To discuss PBI techniques, dose/fractionation, and patient selection criteria.

Main Methods:

Review of key randomized controlled trials, including NSABP B39/RTOG 0413 and the Canadian RAPID trial.
Analysis of comparative data between WBI and PBI outcomes.

Main Results:

RCTs provide crucial data on the efficacy and safety of PBI versus WBI.
Results from major trials are now available to inform clinical practice.

Conclusions:

PBI is a viable alternative to WBI for select early-stage breast cancer patients.
Further review of PBI techniques and patient selection is warranted for optimal outcomes.