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Updated: Dec 20, 2025

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
Case for diagnosis. Single-digit clubbing.
Larissa Crestani1, Isaura Azevedo Fasciani1, Priscila Kakizaki1
1Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.
Single-digit clubbing, a rare condition, was diagnosed as superficial acral fibromyxoma in a 58-year-old female. This case highlights the importance of considering this rare tumor in the differential diagnosis of digital clubbing.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Digital clubbing, characterized by bulbous enlargement of terminal phalanges, can indicate underlying systemic disease.
- While often associated with pulmonary or cardiac conditions, rare causes like superficial acral fibromyxoma require consideration.
Observation:
- A 58-year-old female presented with a two-year history of single-digit clubbing affecting the second finger of her right hand.
- Diagnostic workup included imaging and incisional biopsy of the affected digit.
Findings:
- Histopathological examination and imaging confirmed the diagnosis of superficial acral fibromyxoma.
- Superficial acral fibromyxoma is a rare soft tissue tumor typically affecting the digits.
Implications:
- This case underscores the importance of a comprehensive diagnostic approach for digital clubbing.
- Early recognition and diagnosis of superficial acral fibromyxoma are crucial for appropriate management and to rule out other potential etiologies of digital clubbing.
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