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Regulation of the pentose phosphate cycle in bass (Dicentrarchus labrax L.) liver
M M Medina-Puerta1, M Gallego-Iniesta, A Garrido-Pertierra
1Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
Revista Espanola De Fisiologia
|December 1, 1988
Abstract:
The influence in the activities of the glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase produced by the ratio changes NADPH/NADP is studied. The intracellular ratios of 20 and 10 are enough to achieve total inhibition of these two enzymes, respectively. Measurements of a number of metabolic intermediates show that the concentrations of Krebs cycle compounds are higher than those of glycolytic pathway metabolites. From a consideration of these values, the regulation of the pentose phosphate cycle mainly by the intracellular NADPH/NADP ratio, is discussed.