Related Experiment Video
Updated: Dec 20, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
Effects of flexible ureteroscopy on kidney: A prospective clinical trial
Kasım Ertaş1, Mustafa Zafer Temiz1, Aykut Çolakerol1
1Department of Urology, Bağcılar Training and Research Hospital, İstanbul, Turkey.
Objective:
To investigate the effects of flexible ureteroscopy (F-URS) on the operated side of a kidney by assessing the renal damage markers, urine neutrophil gelatinase-related lipocalin (NGAL) and serum cystatin-C (Cys-C), and overall kidney function with the measurements of standard serum creatinine and urine albumin and protein levels.
Material And Methods:
A total of 30 patients who underwent F-URS for treatment of upper urinary stone disease were prospectively evaluated. Preoperative serum urea, creatinine, and Cys-C levels were noted. Levels of urine albumin, protein, creatinine, and NGAL in spot urine samples from the operated side of a kidney obtained through the access sheath preoperatively and through the ureteral catheter 1 and 24 hours postoperatively were also measured. Preoperative and postoperative parameter levels were statistically compared.
Results:
The patients' mean age was 46.6±15.9 years. The mean operative and fluoroscopy times were 90.67±32.5 and 3.15±1.43 minutes, respectively. The urine creatinine, albumin, protein, albumin/creatinine, and protein/creatinine levels were similar in preoperative and postoperative periods. Postoperative serum urea, creatinine, and Cys-C levels and urine NGAL and NGAL/creatinine levels were not also found with remarkable changes from the baseline levels.
Conclusion:
F-URS is a safe therapeutic intervention in the treatment of urolithiasis, especially regarding renal damage, and functional outcomes.
More Related Videos
05:34A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
11:47Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
Published on: March 4, 2022
Related Concept Videos
Kidney Transplant II: Surgical Procedure
Imaging Studies V: Intravenous Urography and Retrograde Pyelography
Imaging Studies I: Kidney, Ureter, and Bladder Studies
Imaging Studies II: Ultrasonography
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Urinary Tract Calculi VI: Surgical Management