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Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain

Zheng Sun1,2, Yong Xu1,3

  • 1Department of Molecular and Cellular Biology; Baylor College of Medicine, Houston, Texas.

Endocrinology
|May 26, 2020
PubMed

Insights

Nuclear receptor coactivators (NCOAs) and corepressors (NCORs) are crucial in the brain for regulating behaviors and cognition. Genetic variations in these proteins are linked to neurological and metabolic disorders in humans.

Area of Science:

  • Neuroendocrinology
  • Molecular Biology
  • Genetics

Background:

  • Nuclear receptor coactivators (NCOAs) and corepressors (NCORs) modulate gene expression in response to various stimuli.
  • These proteins are widely expressed in the mammalian brain, suggesting significant roles in neural function.
  • Previous research indicates NCOAs/NCORs involvement in hormonal signaling and behavior.

Purpose of the Study:

  • To review recent findings on the function of NCOAs and NCORs within the central nervous system.
  • To highlight the implications of NCOAs/NCORs in brain regulation and associated disorders.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies utilizing genetic animal models.
  • Examination of human patient data with genetic variants.

Main Results:

  • NCOAs and NCORs play pivotal roles in regulating hormonal signaling, behaviors (sexual, consummatory, locomotor), moods, learning, and memory.
  • Genetic variants of NCOAs or NCORs are associated with human conditions like obesity, hormonal disruption, intellectual disability, and autism spectrum disorders.

Conclusions:

  • NCOAs and NCORs are critical regulators of central nervous system functions.
  • Dysregulation of NCOAs/NCORs contributes to neurological and metabolic diseases.
  • Further research into NCOAs/NCORs is essential for understanding brain function and disease.
Keywords:
behaviorbrainneuroendocrinenuclear receptor corepressor (NCOR)steroid receptor coactivator (SRC)

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