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Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Regulation of cellular senescence by microRNAs

Xingjie Ma1, Qingbin Zheng2, Guangming Zhao2

  • 1Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China; Department of the Central Laboratory, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225000, China.

Mechanisms of Ageing and Development
|May 26, 2020
PubMed

Insights

MicroRNAs (miRNAs) regulate cellular senescence, a key factor in aging and disease. This review explores how miRNAs impact senescence pathways, offering insights into therapeutic strategies for age-related disorders.

Area of Science:

  • Cellular and Molecular Biology
  • Aging Research
  • Epigenetics

Background:

  • Cellular senescence is a state of stable cell cycle arrest, crucial in development and disease.
  • Senescence is triggered by various stressors and linked to aging and age-related disorders.
  • Therapeutic elimination of senescent cells shows promise for healthy aging.

Purpose of the Study:

  • To review the regulatory role of microRNAs (miRNAs) in cellular senescence.
  • To elucidate how miRNAs modulate key senescence pathways, including p16, p53, SASP, and calcium signaling.
  • To provide a comprehensive understanding of miRNA-mediated senescence control.

Main Methods:

  • Literature review focusing on miRNA involvement in senescence.
  • Analysis of molecular mechanisms underlying miRNA regulation of senescence pathways.
  • Synthesis of current knowledge on miRNAs, senescence, and related signaling.

Main Results:

  • miRNAs are critical regulators of senescence at transcriptional and post-transcriptional levels.
  • miRNAs influence major senescence pathways: p16, p53, senescence-associated secretory phenotype (SASP), and calcium signaling.
  • Dysregulation of miRNA-senescence interactions contributes to aging and disease.

Conclusions:

  • miRNAs play a significant role in orchestrating cellular senescence.
  • Understanding miRNA-senescence interplay is vital for developing novel therapeutic interventions for aging and related diseases.
  • Targeting miRNAs offers a promising avenue for modulating senescence and improving healthspan.
Keywords:
Calcium signalingSASPSenescencemiRNAsp16/p53

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