Related Experiment Video
Updated: Dec 20, 2025

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
Utility of d-serine monitoring in kidney disease
Tomonori Kimura1, Atsushi Hesaka1, Yoshitaka Isaka2
1KAGAMI Project, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan; Reverse Translational Research Project, Center for Rare Disease Research, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan; Department of Nephrology, Osaka University Graduate School of Medicine, Japan.
Abstract:
d-Serine, a long-term undetected enantiomer of serine, is now showing its potential as a biomarker for kidney diseases. The intra-body dynamics of d-serine, currently defined by blood levels and urinary excretion dynamics, are useful for a comprehensive assessment of kidney function and disease activity. Thus, widespread adoption of d-serine as a biomarker can resolve the long-standing clinical challenge of the early detection and prognostic prediction of kidney diseases. Accuracy and reliability of the measurements are particularly important because these measurements will affect treatment decisions and thus impact the patient's emotional state and quality of life. Accordingly, this review focuses on current clinical challenges in kidney diseases and the potential for monitoring of d-serine to overcome these issues, and discuss the requirements of accurate quantification.
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Serum Studies: Renal Function Tests
Chronic Kidney Disease III: Interprofessional Care
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

