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Updated: Dec 20, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Renoprotective ganodermaones A and B with rearranged meroterpenoid carbon skelotons from Ganoderma fungi
Jiao-Jiao Zhang1, Fu-Ying Qin1, Xiao-Hui Meng1
1School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China.
Abstract:
Two structurally novel meroterpenoids, ganodermaones A (1) and B (2), were isolated from Ganoderma fungi (G. cochlear and G. lucidum). The structures of 1 and 2 were assigned by spectroscopic, computational, and X-ray diffraction methods. Compounds 1 and 2 represent the first examples of meroterpenoids in Ganoderma fungal species featuring with carbon migration. The plausible biosynthetic pathway for 1 was proposed. Biological evaluation showed that both 1 and 2 could inhibit renal fibrosis in TGF-β1-induced kidney proximal tubular cells.
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