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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

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Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Dec 20, 2025

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

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Update on Lung Cancer Screening.

Andrew R Brownlee1, Jessica S Donington1

  • 1Section of Thoracic Surgery, University of Chicago, Chicago, Illinois.

Seminars in Respiratory and Critical Care Medicine
|May 26, 2020
PubMed
Summary

Low-dose computed tomography (LDCT) effectively reduces lung cancer mortality, but adoption rates remain low. This review covers LDCT screening evidence, risks, costs, and implementation challenges.

Area of Science:

  • Pulmonology
  • Radiology
  • Oncology

Background:

  • Lung cancer screening using low-dose computed tomography (LDCT) has advanced significantly over the last decade.
  • Major trials like the National Lung Screening Trial and NELSON trial demonstrate LDCT's efficacy in reducing lung cancer mortality.
  • Leading health organizations have adopted LDCT screening recommendations, acknowledging its benefits.

Purpose of the Study:

  • To review the evolution and current evidence supporting LDCT for lung cancer screening.
  • To discuss the risks, costs, and implementation challenges associated with LDCT screening programs.
  • To provide a comprehensive overview for healthcare professionals and policymakers.

Main Methods:

  • Review of key clinical trials and guidelines on lung cancer screening.

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  • Analysis of evidence for LDCT efficacy in reducing lung cancer mortality.
  • Discussion of practical aspects of implementing LDCT screening programs.
  • Main Results:

    • Strong evidence supports LDCT's effectiveness in decreasing lung cancer deaths.
    • Despite proven benefits, national adoption and implementation rates of LDCT screening are suboptimal.
    • Significant challenges exist in widespread program implementation.

    Conclusions:

    • LDCT is a proven tool for lung cancer mortality reduction.
    • Addressing barriers to adoption and implementation is crucial for maximizing public health benefits.
    • Continued research and policy efforts are needed to optimize lung cancer screening programs.