[Evaluation of the effect of sleep on inflammatory bowel disease patients based on propensity score matching]

Objective: To evaluate the sleep status and the correlation of sleep status with inflammatory bowel disease (IBD). Methods: A case-control study was carried out, including 568 IBD patients including 188 ucerative colitis (UC) patients and 380 Crohn's disease (CD) patients at 36 hospitals from January 1, 2018 to August 31, 2019, and 671 family members and healthy controls from the same cities. The survey consisted of three parts including general demographic data, clinical characteristics and sleep related factors by questionnaires. The items for sleep related factor included sleep duration on work days, sleep duration on weekends, sleep quality, sleep adequacy, snoring, sleep apnea and sleep hand foot movement. R language was used for propensity score and SPSS was used for statistical analysis. Results: The proportion of poor sleep quality before onset in UC and CD was higher than that in healthy control group (CD: 14.5% vs 5.3%, P<0.001; UC: 15.1% vs 5.4%, P<0.001). In CD group, the proportion of snoring before onset (31.3% vs 44.3%, P<0.001) and apnea (0.9% vs 5.5%, P=0.001) was lower than that in heathy control group. The proportion of athetosis in CD was higher than that in healthy control group (35.4% vs 28.9%, P=0.045). Conclusion: Patients with UC and CD have poor sleep quality before the onset of the disease, especially in CD patients.