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Updated: Dec 20, 2025

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
Published on: July 20, 2022
Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
Pietro Scaduto1,2, Adolfo Sequeira3, Marquis P Vawter3
1Department of Neurology, Mitchell Center for Neurodegenerative Diseases. School of Medicine. University of Texas Medical Branch at Galveston, Galveston, USA.
Abstract:
The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.
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