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Updated: Dec 20, 2025

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices

Published on: November 1, 2007

Microfluidic device fabrication mediated by surface chemical bonding.

Rajamanickam Sivakumar¹, Nae Yoon Lee²

¹Department of Industrial and Environmental Engineering, College of Industrial Environmental Engineering, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, Korea.

|May 27, 2020

Summary

Surface chemical bonding enables mild fabrication of microfluidic devices. This method is crucial for bonding polydimethylsiloxane (PDMS) with rigid materials at room temperature, ensuring strong seals.

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Area of Science:

Materials Science
Chemical Engineering
Biotechnology

Background:

Microfluidic devices are essential for various applications, requiring robust fabrication methods.
Traditional bonding techniques often involve harsh conditions, limiting material compatibility and device complexity.
Developing mild and effective bonding strategies is critical for advancing microfluidic technology.

Purpose of the Study:

To review diverse bonding strategies for microfluidic device fabrication.
To emphasize surface chemical modification for bonding under mild conditions (room temperature, atmospheric pressure).
To analyze the role of surface chemical bonding, particularly for polydimethylsiloxane (PDMS) and thermoplastics.

Main Methods:

Comprehensive literature review of microfluidic bonding techniques.

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Last Updated: Dec 20, 2025

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices

Published on: November 1, 2007

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Published on: January 17, 2017

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Analysis of surface modification methods for enhanced adhesion.

Evaluation of bonding processes for silicon, glass, thermoplastics, and elastomers.

Main Results:

Surface chemical bonding is highlighted as a key method for facile microfluidic device assembly.
This approach facilitates bonding of polydimethylsiloxane (PDMS) with thermoplastics under mild conditions.
The review details various bonding methods including anodic, fusion, thermal, and solvent bonding.

Conclusions:

Surface chemical modification is vital for bonding elastomers like PDMS with rigid materials at room temperature.
Mild bonding conditions are achievable and crucial for fabricating advanced microfluidic devices.
Understanding bond strengths is essential for reliable microfluidic system performance.