Dengue vaccine: a key for prevention.

Area of Science:

• * Virology and Immunology
• * Vaccine Development and Public Health

Background:

• * Dengue is a significant global health challenge, primarily transmitted by mosquitoes.
• * Existing vector control strategies have shown limited efficacy in reducing dengue transmission.
• * The economic burden of dengue on health systems and society is substantial.

Purpose of the Study:

• * To review the current landscape of dengue vaccine development.
• * To discuss candidate dengue vaccines progressing through clinical trials.
• * To examine the status of licensed dengue vaccines.

Main Methods:

• * Comprehensive literature review of dengue vaccine research.
• * Analysis of candidate vaccines in preclinical and clinical development.
• * Inclusion of licensed dengue vaccines in the review.

Main Results:

• * Dengue vaccine development is complex due to the disease's unique nature.
• * An advanced pipeline of vaccine candidates exists, including live-attenuated, virus-vectored, and virus-like particle-based vaccines.
• * Both preclinical and clinical studies are actively contributing to vaccine research.

Conclusions:

• * A dengue vaccine is essential for an integrated approach to disease prevention and control.
• * Despite challenges, significant progress in dengue vaccine research offers hope for future control.
• * Continued research and development are vital to combat the global dengue burden.