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Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis
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Feline chimerism revealed by DNA profiling.

Ambre Jaraud1, Philippe Bossé1, Caroline Dufaure de Citres2

  • 1U955 - IMRB - Team 10 - Biology of the neuromuscular system, Inserm, UPEC, EFS , École nationale vétérinaire d'Alfort, Maisons-Alfort, France.

Animal Genetics
|May 27, 2020
PubMed
Summary

This study identified a rare female feline chimera using its unique tortoiseshell coat color. DNA profiling confirmed the chimera, ruling out other genetic conditions like mosaicism.

Keywords:
DNA profileFelis catusMLPHcatchimeracoat colourdispermymicrosatellitezygote

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Area of Science:

  • Genetics
  • Animal Biology
  • Zoology

Background:

  • Chimerism can cause unusual coat color phenotypes in domestic animals like cats.
  • Tortoiseshell coat color in male cats is a known indicator of chimerism.
  • Previous diagnoses of male chimeras often lacked molecular confirmation.

Observation:

  • A domestic cat presented with a tortoiseshell coat, a phenotype typically associated with female cats.
  • The cat's coat color prompted investigation into potential chimerism.
  • The tortoiseshell phenotype in this case was observed in a female cat.

Findings:

  • The female cat was identified as a chimera through its coat color.
  • DNA profiling and a coat color test provided molecular confirmation of chimerism.
  • Genetic analyses excluded mosaicism and aneuploidy as explanations for the observed phenotype.

Implications:

  • This case provides molecular evidence for natural female feline chimerism.
  • Understanding chimerism enhances knowledge of feline genetics and coat color determination.
  • The study highlights the importance of molecular confirmation in diagnosing animal chimeras.