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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
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Murine Ileocolic Bowel Resection with Primary Anastomosis
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Decrease in primary but not in secondary abdominal surgery for Crohn's disease: nationwide cohort study, 1990-2014.

T D Kalman1, Å H Everhov2,3, C Nordenvall4,5

  • 1Division of Surgery, Department of Clinical and Experimental Medicine, Faulty of Health Sciences, Linköping University, Department of Surgery, County Council of Östergötland, Linköping, Sweden.

The British Journal of Surgery
|May 27, 2020
PubMed
Summary
This summary is machine-generated.

Surgical intervention for Crohn's disease has decreased, but repeat surgery rates remain stable. This study analyzes trends in Crohn's disease surgery incidence over time.

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Area of Science:

  • Gastroenterology and Hepatology
  • Surgical Gastroenterology
  • Epidemiology

Background:

  • Crohn's disease treatment has evolved with increased immunomodulatory and biologic therapies since the 1990s.
  • Active disease monitoring has also become more prevalent.
  • The impact of these changes on surgical resection rates is debated.

Purpose of the Study:

  • To investigate the trends in primary and repeat surgical resection for Crohn's disease.
  • To assess the influence of evolving treatment strategies on surgical outcomes.

Main Methods:

  • Nationwide cohort study using the Swedish National Patient Registry (1990-2014).
  • Inclusion of all incident Crohn's disease patients across different diagnostic periods.
  • Estimation of cumulative incidence of first and repeat abdominal surgery using Kaplan-Meier method.

Main Results:

  • The 5-year cumulative incidence of first abdominal surgery for Crohn's disease significantly decreased from 54.8% (1990-1995) to 40.4% (1996-2000) and 17.3% (2009-2014).
  • Repeat 5-year surgery rates showed a decrease from 18.9% (1990-1995) to 16.0% (1996-2000).
  • No significant decreases in surgery rates were observed after the year 2000.

Conclusions:

  • The 5-year rate of surgical intervention for Crohn's disease has significantly decreased.
  • Despite the introduction of biological therapy, the rate of repeat surgery for Crohn's disease has remained stable since 2000.