Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts.

Epilepsia·2026
Same author

Effects of Light Intervention on Insomnia Severity, Fatigue, and Emotional Distress in Patients With Gynecologic Cancer: A Randomized Controlled Trial.

Cancer nursing·2026
Same author

Do coexistent overactive bladder symptoms affect the outcome of single-incision sling in women with urodynamic stress incontinence?

Taiwanese journal of obstetrics & gynecology·2026
Same author

Type 2 Diabetes Intensifies Nocturnal and Early Morning Circadian Autonomic Dysregulation After Ischaemic Stroke.

Journal of diabetes research·2026
Same author

Extracellular vesicles derived from human amniotic fluid stem cells improve bladder dysfunction in rat model of diabetic atherosclerosis.

World journal of stem cells·2026
Same author

Amniotic fluid stem cell-derived extracellular vesicles enhance functional recovery of neurogenic bladder and neurovascular plasticity after cerebral ischemia in rats.

Life sciences·2026

Related Experiment Video

Updated: Dec 20, 2025

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

931

Amniotic Fluid Stem Cells Improve Rat Bladder Dysfunction After Pelvic Nerve Transection.

Ching-Chung Liang1,2, Sheng-Wen Steven Shaw2,3,4, Hung-Hsueh Chou2,5

  • 1Female Urology Section, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan.

Cell Transplantation
|May 27, 2020
PubMed
Summary
This summary is machine-generated.

Human amniotic fluid stem cells (hAFSCs) transplantation improved bladder dysfunction following pelvic nerve transection (PNT) in rats. This therapy promoted nerve regeneration and restored bladder function, indicating potential therapeutic benefits.

Keywords:
amniotic fluid stem cellanimal modelneurogenic bladderpelvic nerve transectionrat

More Related Videos

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.7K
A Radio-telemetric System to Monitor Cardiovascular Function in Rats with Spinal Cord Transection and Embryonic Neural Stem Cell Grafts
07:59

A Radio-telemetric System to Monitor Cardiovascular Function in Rats with Spinal Cord Transection and Embryonic Neural Stem Cell Grafts

Published on: October 7, 2014

10.8K

Related Experiment Videos

Last Updated: Dec 20, 2025

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
04:08

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

931
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.7K
A Radio-telemetric System to Monitor Cardiovascular Function in Rats with Spinal Cord Transection and Embryonic Neural Stem Cell Grafts
07:59

A Radio-telemetric System to Monitor Cardiovascular Function in Rats with Spinal Cord Transection and Embryonic Neural Stem Cell Grafts

Published on: October 7, 2014

10.8K

Area of Science:

  • Regenerative Medicine
  • Urology
  • Neuroscience

Background:

  • Pelvic nerve transection (PNT) causes significant bladder dysfunction.
  • The therapeutic potential of human amniotic fluid stem cells (hAFSCs) for PNT-induced bladder issues is not well understood.

Purpose of the Study:

  • To investigate the efficacy of hAFSCs transplantation in ameliorating bladder dysfunction after PNT in a rat model.
  • To explore the underlying mechanisms involving nerve regeneration and molecular changes.

Main Methods:

  • Female Sprague-Dawley rats underwent sham operation, unilateral PNT, bilateral PNT, or PNT with hAFSCs transplantation.
  • Functional bladder assessment via cystometry.
  • Analysis of neurofilament density and expression of key proteins (PGP9.5, GAP-43, NGF, p75, enkephalin) in bladder tissue.

Main Results:

  • hAFSCs transplantation significantly improved cystometric parameters, including bladder capacity, voiding pressure, and incontinence, in PNT rats.
  • Transplantation led to increased neurofilament density and normalized expression of PGP9.5, GAP-43, NGF, and p75.
  • Changes in enkephalin expression were also observed and improved post-transplantation.

Conclusions:

  • hAFSCs transplantation is a promising therapy for bladder dysfunction induced by PNT.
  • The regenerative effects involve the modulation of neurofilament markers and neurotrophic factors, suggesting a role in nerve repair.