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Updated: Dec 20, 2025

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
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Future of Diagnostic Computed Tomography: An Update on Physicochemical Properties, Safety, and Development of X-ray
Imran Shahid1, Eric Lancelot, Pierre Desché
1From Guerbet, Roissy CDG Cedex, France.
Abstract:
Iodinated contrast media (CM) are utilized in approximately 40% of the 300 million computed tomography (CT) scans undertaken annually. This review focuses on the physicochemical properties and safety of iodinated CM, and the development of new x-ray CM, and it explores methods to optimize CT scanning parameters. It concludes that good x-ray CM should have high structural stability, hydrophilicity, and CT attenuation; low viscosity, osmolality, and protein binding; no metabolism and tissue accumulation; and a complete elimination.
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