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Mediation analysis for the relationship between dyslipidemia and coronary artery disease via hypersensitive
Pan He1, Si-Yu Fan1, Jie-Qiong Guan1
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing.
Insights
Hypersensitive C-reactive protein (hs-CRP) partially mediates the link between dyslipidemia and coronary artery disease (CAD). This finding highlights hs-CRP
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Lipid Metabolism
Background:
- Coronary artery disease (CAD) pathogenesis involves atherosclerosis, inflammation, and dyslipidemia.
- The precise role of hypersensitive C-reactive protein (hs-CRP) in lipid metabolism and CAD development remains unclear.
Purpose of the Study:
- To investigate if hs-CRP levels mediate the association between dyslipidemia and CAD.
- To elucidate the role of hs-CRP in the pathogenesis of coronary artery disease.
Main Methods:
- Analysis of 315 pairs of CAD and non-CAD subjects.
- Clinical history, hs-CRP, and lipid levels were collected.
- Linear regression, logistic regression, and mediation analyses were employed.
Main Results:
- Both dyslipidemia and elevated hs-CRP levels correlated significantly with increased CAD risk.
- A significant correlation was observed between dyslipidemia and hs-CRP levels.
- Mediation analysis indicated that hs-CRP accounted for 8.27% of the association between dyslipidemia and CAD.
Conclusions:
- Hs-CRP plays a partial mediating role in the relationship between dyslipidemia and CAD.
- Understanding this mediation pathway may offer new insights into CAD prevention and treatment strategies.
Background:
The pathological basis of coronary artery disease (CAD) is atherosclerosis which is associated with inflammation and dyslipidemia. However, the involvement of hypersensitive C-reactive protein (hs-CRP) in lipid metabolism and how it affects the pathogenesis of CAD is uncertain.
Objective:
To explore whether the relationship between dyslipidemia and CAD is partly mediated by hs-CRP levels.
Methods:
Three hundred fifteen pairs of randomly sexand age-matched CAD and non-CAD subjects collected from Zhongda Hospital Affiliated to Southeast University were involved in the final analysis. We gathered information about each subjects clinical history as well as their results of detected hs-CRP and lipid levels. Linear regression analysis was used to determine the association between dyslipidemia and hs-CRP levels in which univariate and multivariate logistic regression analyzes were performed to determine the relationship between hs-CRP levels and CAD as well as dyslipidemia and CAD. Mediation analysis was used to evaluate whether hs-CRP levels act as a mediator of the relationship between dyslipidemia and CAD.
Results:
Dyslipidemia and hs-CRP levels were significantly associated with an increased risk of CAD, with β = 0.594 (P = 0.001) and β = 0.016 (P = 0.024), respectively, and there was a correlation between dyslipidemia and hs-CRP levels (β = 3.273, P = 0.004). Mediation analysis results revealed that the correlation between dyslipidemia and CAD was 8.27% mediated by hs-CRP levels with a direct effect of 0.621 and an indirect effect of 0.056.
Conclusion:
Hs-CRP levels played a partial mediation role in the association between dyslipidemia and CAD.
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