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Adverse ocular effects to systemic drug therapy

Cecília Czakó1, Gábor Sándor1, Hajnalka Horváth1

  • 1Általános Orvostudományi Kar, Szemészeti Klinika,Semmelweis Egyetem Budapest, Üllői út 26., 1085.

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Summary

Systemic drugs can cause serious eye problems, including vision loss. Regular eye screenings help detect and manage these drug-induced ocular toxicities early, often preventing permanent damage.

Keywords:
intraoperative floppy iris syndromeintraoperatív ’floppy’ iris szindrómaocular side effectsoptic neuropathyopticus neuropathiasystemic medicationsszemészeti mellékhatásokszisztémás gyógyszerektoxic retinopathytoxikus retinopathia

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Toxicology

Background:

  • Systemic medications can cause a spectrum of ocular adverse effects.
  • These effects range from asymptomatic lesions to severe complications like toxic retinopathy and optic neuropathy.
  • Drug-induced eye disorders pose a significant risk to vision.

Purpose of the Study:

  • To review major systemic drugs with common and significant ocular side effects.
  • To emphasize the importance of ophthalmological screening for early detection of drug toxicity.
  • To highlight the potential for prevention and reversal of drug-induced eye disorders.

Main Methods:

  • Literature review of major drugs and their ocular side effects.
  • Focus on drugs with common and significant ophthalmological manifestations.
  • Analysis of the role of early detection through screening.

Main Results:

  • Identified major drugs associated with significant ocular toxicity.
  • Demonstrated that early detection of toxic effects during screening can prevent or reverse most drug-induced eye disorders.
  • Highlighted specific conditions such as toxic retinopathy and optic neuropathy.

Conclusions:

  • Physicians must be aware of ocular toxicity risks associated with systemic medications.
  • Regular ophthalmological screening is crucial for managing drug-induced eye disorders.
  • Proactive monitoring can mitigate potentially blinding complications.