Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.1K

Procoagulation, hypercoagulation and fibrinolytic “shut down” detected with ClotPro® viscoelastic tests in COVID-19

István Zátroch1, Anikó Smudla2, Barna Babik3

  • 1Uzsoki Utcai Kórház Budapest.

Orvosi Hetilap
|May 27, 2020
PubMed

Insights

COVID-19 patients exhibit significant coagulation issues, including hypercoagulation and impaired fibrinolysis, as detected by ClotPro® tests. These findings suggest a need for further research into anticoagulation therapies for thromboembolic events.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • COVID-19 is associated with a high incidence of thromboembolic events, affecting over 30% of hospitalized patients.
  • These events involve arterial, venous, and microvascular thrombosis, often presenting as disseminated intravascular coagulation (DIC).
  • Key indicators include elevated D-dimer and fibrinogen, alongside prolonged prothrombin time and activated partial thromboplastin time.

Purpose of the Study:

  • To analyze the coagulation status of COVID-19 patients using advanced ClotPro® testing.
  • To correlate laboratory findings with the clinical presentation of thromboembolic complications in COVID-19.

Main Methods:

  • Blood samples from three intensive care unit COVID-19 patients were analyzed.
  • Utilized ClotPro® assays including EX-tests, IN-test, FIB-tests, RVV-tests, and TPA-tests.
  • Results were interpreted in the context of each patient's clinical condition.

Main Results:

  • ClotPro® testing revealed procoagulation, hypercoagulation, and either fibrinolysis or a shutdown of the fibrinolytic process.
  • Coagulation parameters aligned with conventional tests, meeting criteria for non-overt disseminated intravascular coagulation.
  • The findings provide insights into the complex hemostatic alterations in COVID-19.

Conclusions:

  • The study highlights significant coagulation abnormalities in COVID-19 patients.
  • Findings support further investigation into the pathophysiology of COVID-19-related thromboembolism.
  • Results may inform the use of full-dose anticoagulation and antiplatelet therapies, pending clinical trials.
Abstract

Keywords:
COVID-19COVID–19ClotPro®fibrinolysis “shut down”fibrinolysis „shut down”hypercoagulatiohypercoagulationthromboembolic complicationthromboemboliás szövődmények

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.3K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.2K

Related Concept Videos

Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.1K
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.1K
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.4K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.4K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
205
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.8K