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Related Experiment Videos

Eosinophils in nasal secretion.

K Masuyama1, Y Samejima, T Ishikawa

  • 1Department of Otorhinolaryngology, Kumamoto University, School of Medicine, Japan.

Acta Oto-Laryngologica. Supplementum
|January 1, 1988
PubMed
Summary

Eosinophils migrate through nasal epithelial junctions, and nasal secretions contain a heat-sensitive factor that attracts them, indicating an activated state in allergic rhinitis.

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Area of Science:

  • Immunology
  • Cell Biology
  • Rhinology

Background:

  • Eosinophils play a role in allergic inflammation.
  • Understanding eosinophil migration in the nasal passages is crucial for allergic rhinitis research.

Purpose of the Study:

  • To investigate the migration mechanism of eosinophils in the nasal mucosa.
  • To characterize eosinophils within nasal secretions.
  • To identify factors in nasal secretions that influence eosinophil behavior.

Main Methods:

  • Electron microscopy of nasal mucosa (animal and human).
  • Freeze-fracture studies of tight junctions in experimental animals.
  • Physicochemical analysis of nasal secretions from allergic rhinitis patients.

Main Results:

  • Eosinophils were observed migrating through intercellular spaces and disrupting epithelial cell junctions.
  • Tight junctions showed minimal changes, with a slight decrease in strands after antigen challenge.
  • Nasal secretions exhibited eosinophilotactic activity mediated by a small, heat-sensitive molecule.
  • Eosinophils in nasal secretions were hypodense, suggesting activation.

Conclusions:

  • Eosinophil migration in the nasal mucosa involves breaching epithelial cell junctions.
  • Nasal secretions contain chemoattractants for eosinophils, contributing to allergic inflammation.
  • Hypodense eosinophils in nasal secretions indicate an activated phenotype in allergic rhinitis.

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