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Updated: Dec 20, 2025

Remote Laboratory Management: Respiratory Virus Diagnostics
Published on: April 6, 2019
Measles is Back - Considerations for laboratory diagnosis
J J Dunn1, F Baldanti2, E Puchhammer3
1Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA; Department of Pathology, Texas Children's Hospital, Houston, TX, USA.
Abstract:
Measles is a highly contagious viral illness that continues to cause significant mortality among young children worldwide despite the availability of a safe and effective vaccine. During the first half of 2019, over 182 countries reported more than 300,000 measles cases; greater than double the number from the same period in 2018. Timely recognition and laboratory confirmation of infected individuals as well as appropriate infection prevention measures are crucial to avert further transmission. This review highlights the importance of early recognition of the signs and symptoms of measles and provides details on the laboratory methods commonly employed to confirm cases, investigate outbreaks and characterize the virus. It's critical that clinicians, laboratorians and public health administrations work together to rapidly identify, confirm and contain the spread of measles globally.
Insights
Measles, a contagious viral illness, causes high child mortality globally. Early recognition, laboratory confirmation, and public health collaboration are vital to control outbreaks and prevent transmission.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Measles remains a significant global health threat, causing substantial mortality in young children.
- Despite vaccine availability, measles outbreaks persist, with a notable increase in cases reported worldwide.
- The high contagiousness of measles necessitates rapid identification and containment strategies.
Purpose of the Study:
- To emphasize the critical role of early measles symptom recognition.
- To detail laboratory methods for measles case confirmation and virus characterization.
- To underscore the importance of interdisciplinary collaboration for global measles control.
Main Methods:
- Review of current literature on measles epidemiology and clinical presentation.
- Description of standard and advanced laboratory diagnostic techniques for measles virus.
- Analysis of public health strategies for outbreak investigation and control.
Main Results:
- Measles cases have significantly increased globally, highlighting vaccine-preventable disease challenges.
- Early clinical recognition combined with prompt laboratory confirmation is essential for effective outbreak management.
- Molecular methods aid in virus characterization and tracking transmission patterns.
Conclusions:
- Integrated clinical and laboratory approaches are crucial for timely measles diagnosis.
- Collaborative efforts between healthcare providers, laboratories, and public health agencies are vital to contain measles spread.
- Continued vigilance and robust public health interventions are necessary to reduce measles morbidity and mortality worldwide.
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