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Updated: Dec 20, 2025
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
The Effect of Sumatriptan in Ischemic Conditions in the Rat Heart
Hande Özge Altunkaynak-Çamca1, Müge Tecder-Ünal1, Meral Tuncer1
1Başkent University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey.
Objectives:
The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection.
Materials And Methods:
The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC. The mean arterial blood pressure and heart rate were recorded to calculate PRP. Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters.
Results:
The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p<0.05). The incidence of VT in the IPC, SUM-IR, and SUM-IPC groups was significantly lower than in the IR group (p<0.05). VF was only observed in the IR group.
Conclusion:
SUM protects the heart against IR injury but is not as protective as IPC alone. Although SUM diminishes IPC-induced protection against VT, the preventive effect of SUM against VF may be predictive for cardioprotection in ischemic conditions.
