Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery and therapeutic delivery of microRNAs targeting deregulated glioblastoma pathways inhibits tumor growth in mice.

The Journal of clinical investigation·2026
Same author

Development of PSMA-Targeted Liposomal Zinc for Prostate Cancer Therapy.

Nanomaterials (Basel, Switzerland)·2026
Same author

Microbubble Contrast Agents for Molecular Ultrasound Imaging of Tumor Vasculature.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same author

Social support, resilience, and demoralization in patients with breast cancer: a moderated network analysis.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual-Affinity Platform for High-Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Sustainable N, P co-doped hierarchical porous carbon via coupling phytic acid-melamine assisted hydrothermal carbonization with high temperature activation.

Journal of environmental management·2026

Related Experiment Video

Updated: Dec 20, 2025

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
08:05

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

2.7K

Closed-loop feedback control of microbubble diameter from a flow-focusing microfluidic device.

Yanjun Xie1, Adam J Dixon1, J M Robert Rickel1

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville 22908, USA.

Biomicrofluidics
|May 27, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a real-time microfluidic feedback system to measure and control microbubble size. This innovation allows precise manipulation of microbubbles for various applications.

More Related Videos

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

12.1K
A Microfluidic-based Hydrodynamic Trap for Single Particles
10:13

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

17.1K

Related Experiment Videos

Last Updated: Dec 20, 2025

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
08:05

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

2.7K
A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

12.1K
A Microfluidic-based Hydrodynamic Trap for Single Particles
10:13

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

17.1K

Area of Science:

  • Microfluidics
  • Biotechnology
  • Control Systems

Background:

  • Microfluidic devices are crucial for microbubble and droplet manipulation.
  • Previous studies lacked real-time on-chip measurement and control of microbubble diameter.
  • Flow-focusing devices are commonly used for microbubble generation.

Purpose of the Study:

  • To implement a closed-loop feedback control system for microfluidic devices.
  • To enable real-time measurement and control of microbubble diameter.
  • To enhance the production, sorting, and manipulation of microbubbles.

Main Methods:

  • Integration of on-chip electrodes in a flow-focusing microfluidic device.
  • Development of a closed-loop feedback control system using a proportional-integral controller.
  • Real-time measurement and counting of microbubbles within a specific size range.

Main Results:

  • Successful measurement and control of microbubble diameters between 14-24 micrometers.
  • Validation of on-chip measurements against an optical benchmark.
  • Achieved a maximum microbubble production rate of 10,000 bubbles per second.

Conclusions:

  • The developed system provides precise real-time control over microbubble size in microfluidic devices.
  • This advancement facilitates improved applications in microbubble production and manipulation.
  • The closed-loop system offers a robust solution for on-chip microfluidic control.